Progression of dopaminergic hypofunction in striatal subregions in Parkinson's disease using [18F]CFT PET
Identifieur interne : 001720 ( Main/Exploration ); précédent : 001719; suivant : 001721Progression of dopaminergic hypofunction in striatal subregions in Parkinson's disease using [18F]CFT PET
Auteurs : Elina Nurmi [Finlande] ; Jörgen Bergman [Finlande] ; Olli Eskola [Finlande] ; Olof Solin [Finlande] ; Tero Vahlberg [Finlande] ; Pirkko Sonninen [Finlande] ; Juha O. Rinne [Finlande]Source :
- Synapse [ 0887-4476 ] ; 2003-06-01.
English descriptors
- KwdEn :
Abstract
The aim of this study was to investigate the progression of dopaminergic hypofunction in striatal subregions in Parkinson's disease (PD). We studied 12 patients with early PD and 11 healthy controls with a dopamine transporter ligand 2β‐carbomethoxy‐3β‐(4‐[18F]‐fluorophenyl)tropane ([18F]CFT) positron emission tomography (PET). The PET scan was carried out twice with an average interval of 2.2 years. The regions of interest (anterior and posterior putamen, caudate nucleus, and cerebellum) were drawn on individual magnetic resonance imaging (MRI) images, matched with the PET images, and copied onto the PET images. At the first PET scan in PD patients, the [18F]CFT uptake in the anterior putamen was 1.92 ± 0.67, which was 45% of the control mean, and in the posterior putamen 1.02 ± 0.55, being only 27% of the control mean. For the caudate nucleus the corresponding figure was 2.55 ± 0.58 (71% of the control mean). The uptake ratios had declined significantly by the time of the second PET scan and the absolute annual rate of decline of the tracer uptake was 0.23 ± 0.14 (P < 0.001) in the anterior putamen, 0.13 ± 0.13 (P = 0.005) in the posterior putamen, and 0.20 ± 0.15 (P < 0.001) in the caudate nucleus. There was a statistically significant difference of the decline in the tracer uptake between the anterior and posterior putamen (P = 0.033). When the rate of progression was calculated compared to the normal control mean, the rate of annual decline was 5.3% in the anterior putamen, 3.3% in the posterior putamen, and 5.6% in the caudate nucleus, without significant changes among striatal subregions (P = 0.10). When ipsi‐ and contralateral sides were analyzed separately, the absolute decline of [18F]CFT uptake in the putamen was higher in the side ipsilateral to the predominant symptoms than in the contralateral side (P = 0.035 for anterior putamen and P = 0.026 for posterior putamen). In the caudate nucleus the absolute decline was not different between ipsi‐ and contralateral sides (P = 0.76). In healthy controls, no significant decline of [18F]CFT uptake was detected. The results are suggestive of slower progression in the posterior putamen, where the disease is more advanced, but studies to follow up the same patient at several time points are needed to resolve this question. Synapse 48:109–115, 2003. © 2003 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/syn.10192
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Progression of dopaminergic hypofunction in striatal subregions in Parkinson's disease using [18F]CFT PET</title>
<author><name sortKey="Nurmi, Elina" sort="Nurmi, Elina" uniqKey="Nurmi E" first="Elina" last="Nurmi">Elina Nurmi</name>
</author>
<author><name sortKey="Bergman, Jorgen" sort="Bergman, Jorgen" uniqKey="Bergman J" first="Jörgen" last="Bergman">Jörgen Bergman</name>
</author>
<author><name sortKey="Eskola, Olli" sort="Eskola, Olli" uniqKey="Eskola O" first="Olli" last="Eskola">Olli Eskola</name>
</author>
<author><name sortKey="Solin, Olof" sort="Solin, Olof" uniqKey="Solin O" first="Olof" last="Solin">Olof Solin</name>
</author>
<author><name sortKey="Vahlberg, Tero" sort="Vahlberg, Tero" uniqKey="Vahlberg T" first="Tero" last="Vahlberg">Tero Vahlberg</name>
</author>
<author><name sortKey="Sonninen, Pirkko" sort="Sonninen, Pirkko" uniqKey="Sonninen P" first="Pirkko" last="Sonninen">Pirkko Sonninen</name>
</author>
<author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:F2C840940035C581A4428D1F72F6B3790902B8E6</idno>
<date when="2003" year="2003">2003</date>
<idno type="doi">10.1002/syn.10192</idno>
<idno type="url">https://api.istex.fr/document/F2C840940035C581A4428D1F72F6B3790902B8E6/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">000485</idno>
<idno type="wicri:Area/Main/Curation">000420</idno>
<idno type="wicri:Area/Main/Exploration">001720</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Progression of dopaminergic hypofunction in striatal subregions in Parkinson's disease using [18F]CFT PET</title>
<author><name sortKey="Nurmi, Elina" sort="Nurmi, Elina" uniqKey="Nurmi E" first="Elina" last="Nurmi">Elina Nurmi</name>
<affiliation wicri:level="4"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Neurology, University of Turku, FIN‐20521, Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
<orgName type="university">Université de Turku</orgName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku PET Centre, FIN‐20521, Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bergman, Jorgen" sort="Bergman, Jorgen" uniqKey="Bergman J" first="Jörgen" last="Bergman">Jörgen Bergman</name>
<affiliation wicri:level="3"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku PET Centre, FIN‐20521, Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eskola, Olli" sort="Eskola, Olli" uniqKey="Eskola O" first="Olli" last="Eskola">Olli Eskola</name>
<affiliation wicri:level="3"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku PET Centre, FIN‐20521, Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Solin, Olof" sort="Solin, Olof" uniqKey="Solin O" first="Olof" last="Solin">Olof Solin</name>
<affiliation wicri:level="3"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku PET Centre, FIN‐20521, Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vahlberg, Tero" sort="Vahlberg, Tero" uniqKey="Vahlberg T" first="Tero" last="Vahlberg">Tero Vahlberg</name>
<affiliation wicri:level="4"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Biostatistics, University of Turku, FIN‐20521, Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
<orgName type="university">Université de Turku</orgName>
</affiliation>
</author>
<author><name sortKey="Sonninen, Pirkko" sort="Sonninen, Pirkko" uniqKey="Sonninen P" first="Pirkko" last="Sonninen">Pirkko Sonninen</name>
<affiliation wicri:level="4"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Radiology, University of Turku, FIN‐20521, Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
<orgName type="university">Université de Turku</orgName>
</affiliation>
</author>
<author><name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name>
<affiliation wicri:level="3"><country xml:lang="fr">Finlande</country>
<wicri:regionArea>Turku PET Centre, FIN‐20521, Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Synapse</title>
<title level="j" type="abbrev">Synapse</title>
<idno type="ISSN">0887-4476</idno>
<idno type="eISSN">1098-2396</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2003-06-01">2003-06-01</date>
<biblScope unit="volume">48</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="109">109</biblScope>
<biblScope unit="page" to="115">115</biblScope>
</imprint>
<idno type="ISSN">0887-4476</idno>
</series>
<idno type="istex">F2C840940035C581A4428D1F72F6B3790902B8E6</idno>
<idno type="DOI">10.1002/syn.10192</idno>
<idno type="ArticleID">SYN10192</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0887-4476</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CFT</term>
<term>PET</term>
<term>Parkinson's disease</term>
<term>positron emission tomography</term>
<term>progression</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The aim of this study was to investigate the progression of dopaminergic hypofunction in striatal subregions in Parkinson's disease (PD). We studied 12 patients with early PD and 11 healthy controls with a dopamine transporter ligand 2β‐carbomethoxy‐3β‐(4‐[18F]‐fluorophenyl)tropane ([18F]CFT) positron emission tomography (PET). The PET scan was carried out twice with an average interval of 2.2 years. The regions of interest (anterior and posterior putamen, caudate nucleus, and cerebellum) were drawn on individual magnetic resonance imaging (MRI) images, matched with the PET images, and copied onto the PET images. At the first PET scan in PD patients, the [18F]CFT uptake in the anterior putamen was 1.92 ± 0.67, which was 45% of the control mean, and in the posterior putamen 1.02 ± 0.55, being only 27% of the control mean. For the caudate nucleus the corresponding figure was 2.55 ± 0.58 (71% of the control mean). The uptake ratios had declined significantly by the time of the second PET scan and the absolute annual rate of decline of the tracer uptake was 0.23 ± 0.14 (P < 0.001) in the anterior putamen, 0.13 ± 0.13 (P = 0.005) in the posterior putamen, and 0.20 ± 0.15 (P < 0.001) in the caudate nucleus. There was a statistically significant difference of the decline in the tracer uptake between the anterior and posterior putamen (P = 0.033). When the rate of progression was calculated compared to the normal control mean, the rate of annual decline was 5.3% in the anterior putamen, 3.3% in the posterior putamen, and 5.6% in the caudate nucleus, without significant changes among striatal subregions (P = 0.10). When ipsi‐ and contralateral sides were analyzed separately, the absolute decline of [18F]CFT uptake in the putamen was higher in the side ipsilateral to the predominant symptoms than in the contralateral side (P = 0.035 for anterior putamen and P = 0.026 for posterior putamen). In the caudate nucleus the absolute decline was not different between ipsi‐ and contralateral sides (P = 0.76). In healthy controls, no significant decline of [18F]CFT uptake was detected. The results are suggestive of slower progression in the posterior putamen, where the disease is more advanced, but studies to follow up the same patient at several time points are needed to resolve this question. Synapse 48:109–115, 2003. © 2003 Wiley‐Liss, Inc.</div>
</front>
</TEI>
<affiliations><list><country><li>Finlande</li>
</country>
<region><li>Finlande occidentale</li>
</region>
<settlement><li>Turku</li>
</settlement>
<orgName><li>Université de Turku</li>
</orgName>
</list>
<tree><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Nurmi, Elina" sort="Nurmi, Elina" uniqKey="Nurmi E" first="Elina" last="Nurmi">Elina Nurmi</name>
</region>
<name sortKey="Bergman, Jorgen" sort="Bergman, Jorgen" uniqKey="Bergman J" first="Jörgen" last="Bergman">Jörgen Bergman</name>
<name sortKey="Eskola, Olli" sort="Eskola, Olli" uniqKey="Eskola O" first="Olli" last="Eskola">Olli Eskola</name>
<name sortKey="Nurmi, Elina" sort="Nurmi, Elina" uniqKey="Nurmi E" first="Elina" last="Nurmi">Elina Nurmi</name>
<name sortKey="Rinne, Juha O" sort="Rinne, Juha O" uniqKey="Rinne J" first="Juha O." last="Rinne">Juha O. Rinne</name>
<name sortKey="Solin, Olof" sort="Solin, Olof" uniqKey="Solin O" first="Olof" last="Solin">Olof Solin</name>
<name sortKey="Sonninen, Pirkko" sort="Sonninen, Pirkko" uniqKey="Sonninen P" first="Pirkko" last="Sonninen">Pirkko Sonninen</name>
<name sortKey="Vahlberg, Tero" sort="Vahlberg, Tero" uniqKey="Vahlberg T" first="Tero" last="Vahlberg">Tero Vahlberg</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001720 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001720 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:F2C840940035C581A4428D1F72F6B3790902B8E6 |texte= Progression of dopaminergic hypofunction in striatal subregions in Parkinson's disease using [18F]CFT PET }}
This area was generated with Dilib version V0.6.23. |